© All-Russian National Academy of Mycology, 2001
© A. Sergeev, 1999-2001

  The problem of clinical trials
  From previous trials one can not find "real" efficacy of any antifungal. How can we judge, what trial deserves more confidence? Almost any trial takes the population examined as a whole, with no respect to clinical severity in each case. When designing the study with no stratification in comparison of, say, two anti-hypertensive drugs (e.g. by blood pressure levels) one may not expect the reliable results. So why should we not follow the stratification in a case of onychomycosis?
Fig. 1. Reported cure rates for terbinafine (dark-blue)
and itraconazole (red) from different onychomycosis trials
(adapted from Gupta et al., 2000)
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