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© All-Russian National Academy of Mycology,
2001
© A. Sergeev, 1999-2001
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The
problem of clinical trials |
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 From
previous trials one can not find "real" efficacy of
any antifungal. How can we judge, what trial deserves more confidence?
Almost any trial takes the population examined as a whole,
with no respect to clinical severity in each case. When
designing the study with no stratification in comparison of,
say, two anti-hypertensive drugs (e.g. by blood pressure levels)
one may not expect the reliable results. So why should we not
follow the stratification in a case of onychomycosis?
Fig. 1. Reported cure rates for terbinafine
(dark-blue)
and itraconazole (red) from different onychomycosis trials
(adapted from Gupta et al., 2000) |
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Show
me some examples... |
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