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© All-Russian National Academy of Mycology,
2001
© A. Sergeev, 1999-2001
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First
SCIO trial |
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This
is abstract of EADV 2000
The drugs studied were itraconazole pulsed (400 mg daily in
3 one-week-a-month courses) and terbinafine (250 mg daily for
12 weeks).
The study group consisted of 98 patients (50 men and 48 women
aged 25 to 80) who had successfully completed the systemic treatment
for onychomycosis with any of the regimens listed.
The patients included had SCIO values ranging 12 to 16 at the
start of treatment. None of the patients had received systemic
or topical antifungal treatment before study period.
Forty six patients received terbinafine (group1) and 52 patients
received itraconazole (group 2). Mean SCIO values were 14,3
in the group 1 and 14,9 in the group 2. The etiological agents
of onychomycosis were dermatophytes, in 86,9% of group 1 and
87,7 % of group 2. The study endpoint was set on the 18 month
from the start of treatment.
At the study endpoint all patients were evaluated for clinical
cure. The clinical cure was defined as absence of clinical manifestation
of onychomycosis.
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Give me
results! |
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